Evidente V G, Adler C H, Caviness J N, Gwinn K A
Parkinson's Disease and Movement Disorders Center, Mayo Clinic Scottsdale, Arizona 85259, USA.
Mov Disord. 1998 Sep;13(5):829-31. doi: 10.1002/mds.870130513.
We report seven patients with orthostatic tremor (OT) who were successfully treated with the anticonvulsant gabapentin. Five of the patients had been previously tried on clonazepam, the most commonly used drug for OT, four without any benefit. The degree of improvement perceived by the patients with gabapentin varied from 60-80% (mean 73%). The effective dose of gabapentin ranged from 300-1800 mg/day (mean 1030 mg/day). The side effects were generally mild, transient, and dose-related. Duration of response has so far ranged from 2-22 months (mean 11 months) with all patients still currently benefiting from gabapentin. We conclude that gabapentin may be an effective treatment for OT. Further trials are indicated.
我们报告了7例体位性震颤（OT）患者，他们使用抗惊厥药物加巴喷丁成功得到治疗。其中5例患者之前曾试用过治疗OT最常用的药物氯硝西泮，4例未获任何益处。加巴喷丁治疗的患者自我感觉改善程度为60% - 80%（平均73%）。加巴喷丁的有效剂量为300 - 1800毫克/天（平均1030毫克/天）。副作用一般较轻、短暂且与剂量相关。目前所有患者从加巴喷丁治疗中获益，反应持续时间为2 - 22个月（平均11个月）。我们得出结论，加巴喷丁可能是治疗OT的有效药物。需要进一步试验。
