Lundgren E, Szabo E, Ljunghall S, Bergström R, Holmberg L, Rastad J
Department of Surgery, Uppsala University, S-751 85 Uppsala, Sweden.
BMJ. 1998 Sep 26;317(7162):848-51. doi: 10.1136/bmj.317.7162.848.
To analyse sick leave in women at risk of primary hyperparathyroidism before its diagnosis.
Case-control study nested within a screened cohort of postmenopausal women. Cases were women with hyperparathyroidism without prior knowledge of their disease and no traditional symptoms or complications. Controls were women from the screened population without hyperparathyroidism.
Population based screening within a Swedish community.
48 case-control pairs of women aged 55-70 years.
Sick leave during the 5 years before diagnosis.
Total duration of sickness benefits was longer in the cases than controls, and this discrepancy included sick leave on full time or half time and for periods of longer than a week. Cases had an increased risk of sick leave more than half of the investigated time compared with controls (odds ratio 12). Doctors' certificates showed that the overrepresented sick leave in the cases related mainly to cardiovascular diseases.
Asymptomatic mild primary hyperparathyroidism in postmenopausal women is accompanied by a previously unrecognised morbidity, which has consequences for clinical management of the disorder and its impact on the health economy.
分析原发性甲状旁腺功能亢进症风险女性在诊断前的病假情况。
在绝经后女性筛查队列中进行的病例对照研究。病例为患有甲状旁腺功能亢进症但此前不知自己患病且无传统症状或并发症的女性。对照为筛查人群中未患甲状旁腺功能亢进症的女性。
瑞典社区内基于人群的筛查。
48对年龄在55 - 70岁的病例对照女性。
诊断前5年的病假情况。
病例组的疾病津贴总时长比对照组更长，这种差异包括全时或半时病假以及超过一周时长的病假。与对照组相比，病例组在超过一半的调查时间内病假风险增加（比值比12）。医生证明显示病例组中过多的病假主要与心血管疾病有关。
绝经后女性无症状轻度原发性甲状旁腺功能亢进症伴有此前未被认识到的发病率，这对该疾病的临床管理及其对健康经济的影响具有重要意义。
