DNA拓扑异构酶的结构。
Structure of DNA topoisomerases.
作者信息
Berger J M
机构信息
Division of Biochemistry and Molecular Biology, Department of Molecular and Cellular Biology, 229 Stanley Hall, University of California, Berkeley, Berkeley, CA 94720, USA.
出版信息
Biochim Biophys Acta. 1998 Oct 1;1400(1-3):3-18. doi: 10.1016/s0167-4781(98)00124-9.
PMID:9748476
Abstract
Over the last several years topoisomerases have finally begun to yield to high-resolution structural studies. These models have greatly aided our understanding of the mechanisms of topoisomerase catalysis and drug interactions. This review will cover advances in the structural biology of topoisomerases and discuss their implications for topoisomerase function.
摘要
在过去的几年里，拓扑异构酶终于开始接受高分辨率结构研究。这些模型极大地帮助我们理解拓扑异构酶催化机制和药物相互作用。本综述将涵盖拓扑异构酶结构生物学的进展，并讨论其对拓扑异构酶功能的影响。
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