Toyota H, Ito C, Ohsawa M, Sakurai E, Sato M, Watanabe T
Department of Psychiatry, Tohoku University School of Medicine, Sendai, Japan.
Brain Res. 1998 Aug 17;802(1-2):241-6. doi: 10.1016/s0006-8993(98)00637-4.
This study was conducted to elucidate the role of central histamine (HA) in seizure susceptibility. We stimulated the left amygdala of rats to produce amygdaloid kindling. We sacrificed rats 1 h, 1 week and 1 month after the last kindled seizure, and measured the histamine contents and the histidine decarboxylase (HDC) activities of various brain regions. One hour after the last kindled seizure, we found significant decreases in HA levels in the bilateral amygdala, hippocampus and diencephalon in the kindled group. The HDC activities of the bilateral amygdala and diencephalon were lower in the kindled group than in the control group. One week after the last kindled seizure, we also found a significant decrease in the HA level in the bilateral amygdala. No significant change was found in HA content or HDC activity 1 month after the last kindled seizure. These results suggest that kindling suppresses HA synthesis and that the reduced HA content is maintained until 1 week after the last kindled seizure. The reduced HA may play a role in the acquired kindled seizure susceptibility.
本研究旨在阐明中枢组胺（HA）在癫痫易感性中的作用。我们刺激大鼠的左侧杏仁核以产生杏仁核点燃效应。在最后一次点燃性癫痫发作后1小时、1周和1个月处死大鼠，并测量各个脑区的组胺含量和组氨酸脱羧酶（HDC）活性。在最后一次点燃性癫痫发作后1小时，我们发现点燃组双侧杏仁核、海马和间脑中的HA水平显著降低。点燃组双侧杏仁核和间脑的HDC活性低于对照组。在最后一次点燃性癫痫发作后1周，我们还发现双侧杏仁核中的HA水平显著降低。在最后一次点燃性癫痫发作后1个月，HA含量或HDC活性未发现显著变化。这些结果表明，点燃抑制了HA合成，并且降低的HA含量一直维持到最后一次点燃性癫痫发作后1周。降低的HA可能在获得性点燃癫痫易感性中起作用。
