Nenortas E C, Bodley A L, Shapiro T A
Department of Medicine, Johns Hopkins School of Medicine, 303 Hunterian Building, 725 North Wolfe Street, Baltimore, MD 21205-2186, USA.
Biochim Biophys Acta. 1998 Oct 1;1400(1-3):349-54. doi: 10.1016/s0167-4781(98)00146-8.
The parasitic protozoa are notorious for their bizarre cellular structures and metabolic pathways, a characteristic also true for their nucleic acids. Despite these florid differences from mammalian cells, however, it has proven surprisingly difficult to devise novel chemotherapy against these pathogens. In recent years, the DNA topoisomerases from parasites have been the focus of considerable study, not only because they are intrinsically interesting, but also because they may provide a target for much-needed new antiparasitic chemotherapy.
寄生原生动物以其怪异的细胞结构和代谢途径而臭名昭著，其核酸也具有这一特点。然而，尽管与哺乳动物细胞存在这些显著差异，但事实证明，设计针对这些病原体的新型化疗方法极其困难。近年来，寄生虫的DNA拓扑异构酶一直是大量研究的焦点，这不仅是因为它们本身有趣，还因为它们可能为急需的新型抗寄生虫化疗提供靶点。
