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[心房除颤器或植入式心房转复器。初步结果]

[Atrial defibrillators or implantable atrioverters. Initial results].

作者信息

Lévy S, Taramasco V, Corbelli J L, Mistretta R, Dolla E, Ricard P

机构信息

Service de cardiologie, hôpital Nord, Marseille.

出版信息

Arch Mal Coeur Vaiss. 1998 Jul;91(7):887-91.

PMID:9749182
Abstract

The atrial defibrillator is a new non-pharmacological treatment of atrial fibrillation (AF) for restoration of sinus rhythm. This device has two programmable modes: automatic or activated by the physician or patient. In the automatic mode, the device delivers a shock synchronous with the R wave to restore sinus rhythm when AF is detected. Two patients with paroxysmal AF resistant to pharmacological therapy were included in a study to assess the efficacy and safety of the atrial defibrillator in the mode activated by the physician. The device implanted in the pectoral region is connected to 3 electrodes, two for atrial defibrillation and sensing positioned in the coronary sinus and right atrium respectively and a sensing and pacing electrode in the right ventricle. The right ventricle is paced if a post-shock pause is detected. It is possible to interrogate the device with a programmer using its Holter function and so determine the number of episodes of AF sensed and treated. The number, intensity and energy of the shocks and the parameters of ventricular stimulation are programmable. In these two patients, the atrial defibrillator effectively reduced prolonged episodes of AF with a follow-up of 12 and 7 months. No pro-arrhythmic effects were observed. Further clinical evaluation is under way to assess this new mode of treatment, including the mode activated by the patient, safety and tolerance of the shocks. In our two patients, the treatment of prolonged episodes of AF was followed by reduction of many short or asymptomatic episodes.

摘要

心房除颤器是一种用于恢复窦性心律的新型非药物性房颤(AF)治疗方法。该设备有两种可编程模式:自动模式或由医生或患者激活。在自动模式下,当检测到房颤时,设备会发出与R波同步的电击以恢复窦性心律。一项研究纳入了两名对药物治疗耐药的阵发性房颤患者,以评估医生激活模式下心房除颤器的疗效和安全性。植入胸壁区域的设备连接到3个电极,两个用于心房除颤和感知,分别位于冠状窦和右心房,还有一个位于右心室的感知和起搏电极。如果检测到电击后停顿,则对右心室进行起搏。可以使用编程器通过其动态心电图功能询问该设备,从而确定检测到并治疗的房颤发作次数。电击的次数、强度和能量以及心室刺激参数都是可编程的。在这两名患者中,心房除颤器在12个月和7个月的随访中有效减少了房颤的延长发作。未观察到促心律失常作用。正在进行进一步的临床评估,以评估这种新的治疗模式,包括患者激活模式、电击的安全性和耐受性。在我们的两名患者中,延长的房颤发作得到治疗后,许多短暂或无症状发作减少。

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