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[心房除颤器:梦想还是现实?]

[Atrial defibrillator: dream or reality?].

作者信息

Lévy S

机构信息

Service de cardiologie, Hôpital Nord, Marseille.

出版信息

Arch Mal Coeur Vaiss. 1994 Sep;87 Spec No 3:75-7.

PMID:7786128
Abstract

The experience acquired with the use of automatic ventricular cardiovertor-defibrillator led to the idea of developing an atrial device capable of automatically detecting and reducing atrial fibrillation. The large group of patients with paroxysmal atrial fibrillation not responding to pharmacological therapy makes this a particularly relevant question. The first problem is to define the need of this type of device. There is only one group of patients with resistant and/or poorly tolerated paroxysmal atrial fibrillation in whom non-pharmacological therapy is considered, for example ablation of the AV node with implantation of a pacemaker or surgery. The second problem concerns the technical feasibility of an atrial defibrillator with the difficulty related to the detection of the arrhythmia and atrial defibrillation. The recognition of atrial fibrillation may be envisaged from endocavitary signals with satisfactory specificity and sensitivity. The problems related to atrial defibrillation with low energy shocks have not yet been solved clinically, although experimental studies have given promising results. The possible dangers are dominated by a pro-arrhythmic effect and the risk of ventricular fibrillation, but they could be avoided by synchronizing the atrial shock with ventricular activation based on results also obtained in the animal. Before the dream becomes reality, trials are necessary to develop a safe and effective automatic device. Intermediary stages of evaluation of such a device could include a device activated by the physician.

摘要

使用自动心室心脏复律除颤器所获得的经验催生了研发一种能够自动检测并减少心房颤动的心房装置的想法。大量对阵发性心房颤动无药物治疗反应的患者使得这个问题尤为重要。首要问题是确定这类装置的需求。仅有一组对阵发性心房颤动耐受不良和/或耐药的患者会考虑非药物治疗,例如通过植入起搏器或手术进行房室结消融。第二个问题涉及心房除颤器的技术可行性,这与心律失常检测和心房除颤的难度相关。可通过心腔内信号以令人满意的特异性和敏感性来识别心房颤动。尽管实验研究已取得了有前景的结果,但低能量电击心房除颤相关的问题在临床上尚未得到解决。可能的危险主要是促心律失常效应和心室颤动风险,但根据在动物实验中也获得的结果,通过使心房电击与心室激活同步可以避免这些危险。在梦想成为现实之前,必须进行试验以开发一种安全有效的自动装置。对这种装置进行评估的中间阶段可以包括由医生激活的装置。

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