骨髓和脾脏中巨核细胞感染猪霍乱病毒的免疫组织化学及超微结构证据

Immunohistochemical and ultrastructural evidence of hog cholera virus infection of megakaryocytes in bone marrow and spleen.

作者信息

Gómez-Villamandos J C, Ruiz-Villamor E, Salguero F J, Bautista M J, Carrasco L, Sánchez C, Quezada M, Sierra M A

机构信息

Departamento de Anatomía y Anatomía Patológica Comparadas, Facultad de Veterinaria, Universidad de Córdoba, Spain.

出版信息

J Comp Pathol. 1998 Aug;119(2):111-9. doi: 10.1016/s0021-9975(98)80056-x.

DOI:10.1016/s0021-9975(98)80056-x

PMID:9749356

Abstract

Twelve pigs were inoculated with a highly virulent strain of hog cholera virus (HCV) to study viral infection of megakaryocytes in the bone marrow and spleen. Immunohistochemical and ultrastructural examination revealed HCV infection in a small proportion (2.5-9.0%) of these cells from the 2nd to the 9th day after inoculation, at which time the experiment was terminated. Megakaryocyte infection accounts for the presence of viral antigens in platelets. The latter may represent a passive vehicle for spreading the virus in the animal.

摘要

给12头猪接种高致病性猪瘟病毒（HCV），以研究骨髓和脾脏中巨核细胞的病毒感染情况。免疫组织化学和超微结构检查显示，接种后第2天至第9天，这些细胞中有一小部分（2.5%-9.0%）被HCV感染，此时实验终止。巨核细胞感染是血小板中病毒抗原存在的原因。后者可能是病毒在动物体内传播的被动载体。