[The artificial joint in the biological environment].

The mechanisms of the joint endoprothesis components evolution and wear as well as development periarthric tissue membrane are discussed. The loosing process is connected with immuno-inflammatory reactions in periarthric tissues on products' wear and modified proteins which activate the bone resorption and/or proliferative reactions as ectopic bone formation. Systemic effects of artificial joints can be connected with migration of metal ions and primated in periarthric tissues of immunocompetent cells. It is concluded that in developing new joint endoprotheses there is a necessity in a systemic approach taking into account all well-known peculiarities of this complex biotribological object at present.