Lehéricy S, van de Moortele P F, Lobel E, Paradis A L, Vidailhet M, Frouin V, Neveu P, Agid Y, Marsault C, Le Bihan D
Service Hospitalier Frédéric Joliot, Department of Medical Research, CEA, Orsay, France.
Ann Neurol. 1998 Sep;44(3):398-404. doi: 10.1002/ana.410440319.
The present study aimed at determining the distribution and somatotopical organization of striatal activation during performance of simple motor tasks. Ten right-handed healthy volunteers were studied by using a 3-T whole-body magnetic resonance unit and echo planar imaging. The tasks consisted of self-paced flexion/extension of the right fingers or toes. Motor activation was found mainly in the putamen posterior to the anterior commissure (10 of 10 subjects) and the globus pallidus (6 subjects), whereas the caudate nucleus was activated in only 3 subjects, and in a smaller area. Thus, performance of a simple motor task activated the sensorimotor territory of the basal ganglia. Within the putamen, there was a somatotopical organization of the foot and hand areas similar to that observed in nonhuman primates. These data suggest that functional magnetic resonance imaging can be used to study normal function of the basal ganglia and should therefore also allow investigation of patients with movement disorders.
本研究旨在确定在执行简单运动任务期间纹状体激活的分布及躯体定位组织。通过使用3-T全身磁共振装置和回波平面成像技术对10名右利手健康志愿者进行了研究。任务包括右手指或脚趾的自主屈伸。运动激活主要见于前连合后方的壳核（10名受试者中的10名）和苍白球（6名受试者），而尾状核仅在3名受试者中被激活，且激活区域较小。因此，简单运动任务的执行激活了基底神经节的感觉运动区域。在壳核内，足部和手部区域存在类似于在非人灵长类动物中观察到的躯体定位组织。这些数据表明，功能磁共振成像可用于研究基底神经节的正常功能，因此也应有助于对运动障碍患者进行研究。
