哥伦比亚本土印第安人中的GB病毒C/庚型肝炎病毒感染

GB virus C/hepatitis G virus infection among Colombian native Indians.

作者信息

Tanaka Y, Mizokami M, Orito E, Ohba K, Nakano T, Kato T, Kondo Y, Ding X, Ueda R, Sonoda S, Tajima K, Miura T, Hayami M

机构信息

Second Department of Medicine, Nagoya City University Medical School, Nagoya, Japan.

出版信息

Am J Trop Med Hyg. 1998 Sep;59(3):462-7. doi: 10.4269/ajtmh.1998.59.462.

DOI:10.4269/ajtmh.1998.59.462

PMID:9749645

Abstract

To elucidate the prevalence of GB virus C/hepatitis G virus (GBV-C/HGV) infection in Colombian native Indians, serum GBV-C/HGV RNA was assayed in 163 native Indians and 67 members of the general population in Colombia. The native Indians (males:females = 40:123) and the members of the general population (males:females = 20:47) were tested by reverse transcription-semi-nested polymerase chain reaction. Of the 163 native Indians, 10 (6.1%) were positive for GBV-C/HGV RNA, compared with one (1.5%) of 67 from the general population. All Indians were negative for hepatitis B surface antigen and antibody to hepatitis C virus. Of 10 Indians with GBV-C/HGV RNA, the genotype of nine subjects was the Asian type. These data indicated that 1) the prevalence of GBV-C/HGV RNA in Colombian native Indians is high, and 2) GBV-C/HGV was probably brought from Asia and inherited for generations in some native Indian groups.

摘要

为了阐明哥伦比亚本土印第安人中GB病毒C/庚型肝炎病毒（GBV-C/HGV）感染的流行情况，对163名本土印第安人和67名哥伦比亚普通人群的血清进行了GBV-C/HGV RNA检测。本土印第安人（男:女 = 40:123）和普通人群（男:女 = 20:47）采用逆转录-半巢式聚合酶链反应进行检测。163名本土印第安人中，10人（6.1%）GBV-C/HGV RNA呈阳性，而普通人群67人中只有1人（1.5%）呈阳性。所有印第安人乙肝表面抗原和丙肝病毒抗体均为阴性。在10名GBV-C/HGV RNA呈阳性的印第安人中，9名受试者的基因型为亚洲型。这些数据表明：1）哥伦比亚本土印第安人中GBV-C/HGV RNA的流行率较高；2）GBV-C/HGV可能是从亚洲传入，并在一些本土印第安人群体中代代相传。