DesGroseilliers J P, Shiffman N J
Can Med Assoc J. 1976 Oct 23;115(8):768-70.
Pellagra due to malnutrition occurred in an Ottawa women in 1973. She was given a normal diet with supplements of riboflavin, thiamine, niacin and ascorbic acid. The clinical response was striking. Although pellagra is still common in some parts of the world, it is now rare in North America. The disease may occur secondary to malnutrition or malabsorption; inborn errors of metabolism or transport, as in Hartnup disease; deviation of precursors of niacin, as in carcinoid syndrome; or competitive inhibition of niacin incorporation into nicotinamide-adenine dinucleotide, as with administration of isoniazid.
1973年，渥太华一名女性因营养不良患上糙皮病。她接受了正常饮食，并补充了核黄素、硫胺素、烟酸和抗坏血酸。临床反应显著。尽管糙皮病在世界某些地区仍然常见，但现在在北美已很罕见。该疾病可能继发于营养不良或吸收不良；代谢或转运的先天性缺陷，如在哈氏病中；烟酸前体的偏差，如在类癌综合征中；或烟酸掺入烟酰胺腺嘌呤二核苷酸的竞争性抑制，如使用异烟肼时。
