在实验性脊髓损伤后，碱性成纤维细胞生长因子和酸性成纤维细胞生长因子在体内可保护脊髓运动神经元。

Basic and acidic fibroblast growth factors protect spinal motor neurones in vivo after experimental spinal cord injury.

作者信息

Teng Y D, Mocchetti I, Wrathall J R

机构信息

Department of Cell Biology, Georgetown University, Washington DC 20007, USA.

出版信息

Eur J Neurosci. 1998 Feb;10(2):798-802. doi: 10.1046/j.1460-9568.1998.00100.x.

DOI:10.1046/j.1460-9568.1998.00100.x

PMID:9749747

Abstract

We studied the effect of a single focal injection of recombinant basic (FGF2) or acidic (FGF1) fibroblast growth factor on the survival of spinal motor neurones at 24 h after a standardized spinal cord contusion injury (SCI) in the rat. Both FGF2 and FGF1 (3 microg), microinjected into the injury site at 5 min post-injury (p.i.), protected at least two functionally important classes of spinal motor neurones, autonomic preganglionic neurones in the intermediolateral (IML) column and somatic motor neurones in the ventral horn (VH). Moreover, there was enhanced choline acetyltransferase (ChAT) immunoreactivity in surviving VH and IML neurones, suggesting an improved functional status. Thus, neurotrophic factors such as FGF2 and FGF1 may contribute to an overall strategy to treat acute SCI and improve recovery of function.

摘要

我们研究了在大鼠标准化脊髓挫伤性损伤（SCI）后24小时，单次局部注射重组碱性成纤维细胞生长因子（FGF2）或酸性成纤维细胞生长因子（FGF1）对脊髓运动神经元存活的影响。在损伤后5分钟（p.i.）将FGF2和FGF1（3微克）微量注射到损伤部位，可保护至少两类功能重要的脊髓运动神经元，即中间外侧（IML）柱中的自主神经节前神经元和腹角（VH）中的躯体运动神经元。此外，存活的VH和IML神经元中胆碱乙酰转移酶（ChAT）免疫反应性增强，表明功能状态有所改善。因此，诸如FGF2和FGF1之类的神经营养因子可能有助于制定治疗急性SCI和改善功能恢复的总体策略。