Csermely P, Schnaider T, Soti C, Prohászka Z, Nardai G
Department of Medical Chemistry, Semmelweis University, Budapest, Hungary.
Pharmacol Ther. 1998 Aug;79(2):129-68. doi: 10.1016/s0163-7258(98)00013-8.
The 90-kDa molecular chaperone family (which comprises, among other proteins, the 90-kDa heat-shock protein, hsp90 and the 94-kDa glucose-regulated protein, grp94, major molecular chaperones of the cytosol and of the endoplasmic reticulum, respectively) has become an increasingly active subject of research in the past couple of years. These ubiquitous, well-conserved proteins account for 1-2% of all cellular proteins in most cells. However, their precise function is still far from being elucidated. Their involvement in the aetiology of several autoimmune diseases, in various infections, in recognition of malignant cells, and in antigen-presentation already demonstrates the essential role they likely will play in clinical practice of the next decade. The present review summarizes our current knowledge about the cellular functions, expression, and clinical implications of the 90-kDa molecular chaperone family and some approaches for future research.
90 kDa分子伴侣家族（除其他蛋白质外，还包括90 kDa热休克蛋白hsp90和94 kDa葡萄糖调节蛋白grp94，分别是胞质溶胶和内质网的主要分子伴侣）在过去几年中已成为一个越来越活跃的研究课题。这些普遍存在且高度保守的蛋白质在大多数细胞中占所有细胞蛋白质的1%至2%。然而，它们的确切功能仍远未阐明。它们参与多种自身免疫性疾病的病因、各种感染、恶性细胞的识别以及抗原呈递，这已经表明它们可能会在未来十年的临床实践中发挥重要作用。本综述总结了我们目前关于90 kDa分子伴侣家族的细胞功能、表达和临床意义的知识以及一些未来研究的方法。
