MacLennan G, Stogryn R D, Voitk A J
Cancer. 1976 Aug;38(2):953-6. doi: 10.1002/1097-0142(197608)38:2<953::aid-cncr2820380246>3.0.co;2-4.
Abdominoperineal resection cure adenocarcinoma of the rectum was performed in 62 patients between 1965 and 1969 at the Winnipeg General Hospital. Mean age was 64, ranging from 41 to 83; 40 patients were male and 22 female. Distribution by Dukes' staging was: A, 11; B, 28; C, 23. Complications occurred in 22 patients (35%). Average hospital stay was 29 days, 27 days in uncomplicated patients and 36 days in those with complications. There were two deaths, a 3.2% operative mortality rate. Sixty of the 62 patients were available for 5-year followup. Crude survival rate was 52%: A, 91%; B, 59%; C, 25%. Two patients died of an operation that permanently cured three patients in whom disease had spread beyond local confines. Abdominoperineal resection offered a 52% 5-year survival rate, increased the rate of cures in the unstaged patient by at least 5% over that afforded by local therapy, gave a 14% chance of cure in stage C disease compared with 0% with local therapy, and, compared with local therapy, was at least 67% more likely to offer cure than to kill in the event of disease spread to regional lymph nodes.
1965年至1969年间，温尼伯总医院对62例患者进行了腹会阴联合切除术治疗直肠癌。平均年龄为64岁，范围在41岁至83岁之间；男性40例，女性22例。按杜克分期分布为：A期11例；B期28例；C期23例。22例患者（35%）出现并发症。平均住院时间为29天，无并发症患者为27天，有并发症患者为36天。有2例死亡，手术死亡率为3.2%。62例患者中有60例接受了5年随访。粗生存率为52%：A期91%；B期59%；C期25%。2例患者死于手术，但该手术永久性治愈了3例疾病已扩散至局部范围以外的患者。腹会阴联合切除术的5年生存率为52%，与局部治疗相比，使未分期患者的治愈率提高了至少5%，C期疾病的治愈机会为14%，而局部治疗为0%，并且与局部治疗相比，在疾病扩散至区域淋巴结的情况下，提供治愈的可能性比导致死亡的可能性至少高67%。
