一种用于将互补DNA（cDNA）序列与基因组DNA序列进行比对的计算机程序。
A computer program for aligning a cDNA sequence with a genomic DNA sequence.
作者信息
Florea L, Hartzell G, Zhang Z, Rubin G M, Miller W
机构信息
Department of Computer Science and Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802 USA.
出版信息
Genome Res. 1998 Sep;8(9):967-74. doi: 10.1101/gr.8.9.967.
Abstract
We address the problem of efficiently aligning a transcribed and spliced DNA sequence with a genomic sequence containing that gene, allowing for introns in the genomic sequence and a relatively small number of sequencing errors. A freely available computer program, described herein, solves the problem for a 100-kb genomic sequence in a few seconds on a workstation.
摘要
我们解决了将转录和剪接后的DNA序列与包含该基因的基因组序列进行高效比对的问题，同时考虑基因组序列中的内含子以及相对少量的测序错误。本文所述的一个免费计算机程序，在工作站上只需几秒钟就能解决针对100kb基因组序列的该问题。
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