Lantz C H, Larner J
Cancer Biochem Biophys. 1976 Aug;1(5):229-38.
Rats bearing the Walker 256 intramuscular carcinosarcoma were treated intraperitoneally with tritium-labeled vernolepin or with its nontumor-inhibitory methanol adduct. Following treatment with 3H-vernolepin on several different dosage schedules, the tumors were found to contain significantly more radioactivity per gram wet weight than control tissue (muscle from the contralateral limb). After the administration of the nontumor-inhibitory methanol adduct, no such difference was observed. The distribution of radioactivity in various other organs (liver, kidney, spleen, intestine, lung, heat, fat, blood, and brain) was measured following treatment with the parent compound (3H-vernolepin). The implications of these data in terms of the suggested mechanism of action of sesquiterpene lactone tumor inhibitors is discussed.
携带Walker 256肌内癌肉瘤的大鼠经腹腔注射氚标记的斑鸠菊苦素或其无肿瘤抑制作用的甲醇加合物。在按照几种不同的给药方案用³H-斑鸠菊苦素治疗后，发现肿瘤每克湿重所含的放射性明显高于对照组织（对侧肢体的肌肉）。给予无肿瘤抑制作用的甲醇加合物后，未观察到这种差异。在用母体化合物（³H-斑鸠菊苦素）治疗后，测量了放射性在其他各种器官（肝脏、肾脏、脾脏、肠道、肺、心脏、脂肪、血液和大脑）中的分布。讨论了这些数据对于倍半萜内酯类肿瘤抑制剂作用机制的意义。
