Cohen B B
Cancer Biochem Biophys. 1976 Aug;1(5):251-6.
Ribonuclease inhibitors were found to be present attached to mouse ascites ribosomes and in the post-ribosomal supernatant. Both inhibitors inhibited pancreatic RNAses A and B and two endonucleases prepared from ascites cells but did not inhibit RNAses T1 or N1. Both inhibitors had the same sedimentation coefficient and this taken with the results above suggest that they are identical. The inhibitor was shown to interact directly with the RNAse itself.
人们发现核糖核酸酶抑制剂附着于小鼠腹水核糖体以及核糖体后上清液中。这两种抑制剂均能抑制胰腺核糖核酸酶A和B以及从腹水细胞中制备的两种核酸内切酶，但不抑制核糖核酸酶T1或N1。这两种抑制剂具有相同的沉降系数，结合上述结果表明它们是相同的。已证明该抑制剂可直接与核糖核酸酶本身相互作用。
