Logsdon R G, Teri L, McCurry S M, Gibbons L E, Kukull W A, Larson E B
J Gerontol B Psychol Sci Soc Sci. 1998 Sep;53(5):P294-9. doi: 10.1093/geronb/53b.5.p294.
This study evaluated the frequency, predictors, and effects of wandering in a population-based sample of 193 individuals with Alzheimer's disease (AD). Although wandering occurred in subjects at all levels of cognitive impairment, analysis of variance indicated that for the group as a whole, greater frequency of wandering was associated with significantly more impairment in cognition, day-to-day functioning, and behavior. Caregiver distress also increased significantly with increased frequency of wandering. Logistic regression modeling identified functional impairment and disruptive behavior problems as the strongest independent predictors of wandering occurring within the past week. Cluster analysis revealed four characteristic groups of wanderers that represented a continuum of wandering frequency, each having a unique pattern of other behavioral disturbances. Based on this analysis, we recommend further evaluation and the development of possible treatment strategies that address the individual differences found among AD patients who wander.
本研究评估了193名阿尔茨海默病（AD）患者的基于人群样本中的徘徊频率、预测因素及影响。尽管认知障碍各水平的受试者均出现了徘徊现象，但方差分析表明，对于总体研究组而言，徘徊频率越高，认知、日常功能及行为方面的损害就越显著。随着徘徊频率增加，照料者的痛苦也显著增加。逻辑回归模型确定功能损害和破坏性行为问题是过去一周内出现徘徊的最强独立预测因素。聚类分析揭示了徘徊者的四个特征组，代表了徘徊频率的连续体，每组都有独特的其他行为障碍模式。基于该分析，我们建议进行进一步评估，并制定可能的治疗策略，以应对徘徊的AD患者中发现的个体差异。
