Bera Rathindra Nath, Tripathi Richik, Bhattacharjee Bappaditya, Singh Akhilesh Kumar, Kanojia Shweta, Kumar Vikram
Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Department of Prosthodontics, Faculty of Dental Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Natl J Maxillofac Surg. 2021 May-Aug;12(2):162-170. doi: 10.4103/njms.NJMS_230_20. Epub 2021 Jul 15.
Neurologic disorders impede oral hygiene measures and routine clinical follow-up, along with the various drugs used may jeopardise oral health and the peri- implant tissue health. A total of 7 studies were considered eligible for the current systematic review. The overall estimated effect was categorized as significant where < 0.05. Funnel plot was used to assess the publication bias within the studies. Difference in means was used as principal summary measure. value <0.05 was considered as statistically significant. 1069 implants survived in test group and 4677 implants survived in control group (odds ratio: 2.58, 95% CI: 1.93-3.43) indicating significant success in patient without any disorders or taking medications for these disorders. Subgroup analysis was done to check the implant survival rate in patients taking selective serotonin reuptake inhibitors (SSRI) compared with SSRI non-users. Subgroup analysis showed that SSRI non-users had higher implant survival rate than patients taking SSRI (odds ratio: 2.45, 95% CI: 1.82-3.31). Serotonin significantly inhibits bone mineralization and osteoblast differentiation. The presence of any form of neuropsychiatric or neuromuscular disorders precludes proper oral hygiene and may contribute towards implant failure.
神经系统疾病会妨碍口腔卫生措施和常规临床随访，同时所使用的各种药物可能会损害口腔健康和种植体周围组织健康。共有7项研究被认为符合当前系统评价的条件。总体估计效应在P<0.05时被归类为显著。漏斗图用于评估研究中的发表偏倚。均值差异用作主要汇总指标。P值<0.05被认为具有统计学意义。试验组有1069颗种植体存活，对照组有4677颗种植体存活（优势比：2.58，95%置信区间：1.93 - 3.43），表明在没有任何疾病或未服用治疗这些疾病药物的患者中取得了显著成功。进行亚组分析以检查服用选择性5-羟色胺再摄取抑制剂（SSRI）的患者与未服用SSRI的患者的种植体存活率。亚组分析表明，未服用SSRI的患者的种植体存活率高于服用SSRI的患者（优势比：2.45，95%置信区间：1.82 - 3.31）。5-羟色胺会显著抑制骨矿化和成骨细胞分化。任何形式的神经精神或神经肌肉疾病的存在都会妨碍适当的口腔卫生，并可能导致种植体失败。
