Doucet O, Martin L, Laffon M, Jonville-Bera A P, Mercier C
Unité d'anesthésie-réanimation pédiatrique, hôpital Clocheville, Tours, France.
Ann Fr Anesth Reanim. 1998;17(7):725-7. doi: 10.1016/s0750-7658(98)80109-3.
Mivacurium is a short acting non-depolarising neuromuscular blocking agent. Short duration of action is due to a rapid hydrolysis by plasma cholinesterase (CHe). The duration of neuromuscular blockade can be prolonged by an abnormal variant of CHe. We report a case of a newborn with neuromuscular blockade for a duration of 8 hours following mivacurium 0.2 mg.kg-1. CHe activity values were not contributive for the diagnosis. The diagnosis was obtained with molecular study showing the new-born homozygocity. The whole family was heterozygous. This case emphasises the lack of precision of CHe activity measurement during the first 6 months of life.
米库氯铵是一种短效非去极化神经肌肉阻滞剂。作用持续时间短是由于其被血浆胆碱酯酶（CHe）快速水解。CHe的异常变体可延长神经肌肉阻滞的持续时间。我们报告了一例新生儿在静脉注射0.2mg·kg-1米库氯铵后神经肌肉阻滞持续8小时的病例。CHe活性值对诊断无帮助。通过分子研究确诊为新生儿纯合子，其整个家族均为杂合子。该病例强调了在生命的前6个月内CHe活性测量缺乏准确性。
