Silkoff P E, McClean P A, Slutsky A S, Caramori M, Chapman K R, Gutierrez C, Zamel N
Division of Respiratory Medicine, Faculty of Medicine, The University of Toronto, Canada.
J Asthma. 1998;35(6):473-9. doi: 10.3109/02770909809071000.
The measurement of exhaled nitric oxide (ENO) is recognized as a marker of airway inflammation. ENO was measured in 10 nonsteroid-treated asthmatics at recruitment, during 3 weeks of inhaled beclomethasone (1000 microg/day) and for 3 weeks after withdrawal. Baseline ENO was increased in asthma compared with nonasthmatics (85.0+/-54.5 vs. 24.5+/-14.8 ppb, p < 0.0001). After inhaled steroid, there was no significant change in forced expiratory volume in 1 sec (FEV1) and forced vital capacity (FVC), but methacholine PC20 rose significantly (p = 0.0345). ENO (mean+/-SD; % baseline) fell after 1 week on steroid to 60.6+/-31.1 and rose to 95.3+/-46.1 at 1 week after withdrawal. ENO did not correlate with PC20 or FEV1. The changes in ENO and PC20 were inversely correlated (r2 = 0.325). ENO may be an index of airway inflammation and therapeutic response in bronchial asthma.
呼出一氧化氮（ENO）的测量被认为是气道炎症的一个标志物。在招募时对10名未接受类固醇治疗的哮喘患者进行了ENO测量，在吸入倍氯米松（1000微克/天）3周期间以及停药后3周进行了测量。与非哮喘患者相比，哮喘患者的基线ENO升高（85.0±54.5对24.5±14.8 ppb，p<0.0001）。吸入类固醇后，第1秒用力呼气量（FEV1）和用力肺活量（FVC）无显著变化，但乙酰甲胆碱PC20显著升高（p = 0.0345）。使用类固醇1周后ENO（平均值±标准差；占基线的百分比）降至60.6±31.1，停药1周后升至95.3±46.1。ENO与PC20或FEV1无相关性。ENO和PC20的变化呈负相关（r2 = 0.325）。ENO可能是支气管哮喘气道炎症和治疗反应的一个指标。
