轻度哮喘患者吸入倍氯米松期间及之后的呼出一氧化氮与支气管反应性
Exhaled nitric oxide and bronchial reactivity during and after inhaled beclomethasone in mild asthma.
作者信息
Silkoff P E, McClean P A, Slutsky A S, Caramori M, Chapman K R, Gutierrez C, Zamel N
机构信息
Division of Respiratory Medicine, Faculty of Medicine, The University of Toronto, Canada.
出版信息
J Asthma. 1998;35(6):473-9. doi: 10.3109/02770909809071000.
The measurement of exhaled nitric oxide (ENO) is recognized as a marker of airway inflammation. ENO was measured in 10 nonsteroid-treated asthmatics at recruitment, during 3 weeks of inhaled beclomethasone (1000 microg/day) and for 3 weeks after withdrawal. Baseline ENO was increased in asthma compared with nonasthmatics (85.0+/-54.5 vs. 24.5+/-14.8 ppb, p < 0.0001). After inhaled steroid, there was no significant change in forced expiratory volume in 1 sec (FEV1) and forced vital capacity (FVC), but methacholine PC20 rose significantly (p = 0.0345). ENO (mean+/-SD; % baseline) fell after 1 week on steroid to 60.6+/-31.1 and rose to 95.3+/-46.1 at 1 week after withdrawal. ENO did not correlate with PC20 or FEV1. The changes in ENO and PC20 were inversely correlated (r2 = 0.325). ENO may be an index of airway inflammation and therapeutic response in bronchial asthma.
呼出一氧化氮（ENO）的测量被认为是气道炎症的一个标志物。在招募时对10名未接受类固醇治疗的哮喘患者进行了ENO测量，在吸入倍氯米松（1000微克/天）3周期间以及停药后3周进行了测量。与非哮喘患者相比，哮喘患者的基线ENO升高（85.0±54.5对24.5±14.8 ppb，p<0.0001）。吸入类固醇后，第1秒用力呼气量（FEV1）和用力肺活量（FVC）无显著变化，但乙酰甲胆碱PC20显著升高（p = 0.0345）。使用类固醇1周后ENO（平均值±标准差；占基线的百分比）降至60.6±31.1，停药1周后升至95.3±46.1。ENO与PC20或FEV1无相关性。ENO和PC20的变化呈负相关（r2 = 0.325）。ENO可能是支气管哮喘气道炎症和治疗反应的一个指标。
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