Salviano Luanda Dias da Silva, Taglia-Ferre Karla Delevedove, Lisboa Sandra, Costa Ana Carolina Carioca da, Campos Hisbello da Silva, March Maria de Fátima Pombo
Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira da Fundação Oswaldo Cruz (IFF/Fiocruz), Rio de Janeiro, RJ, Brasil.
Hospital Infantil Nossa Senhora da Glória, Cachoeiro de Itapemirim, ES, Brasil.
Rev Paul Pediatr. 2018 Jan 15;36(1):8. doi: 10.1590/1984-0462/;2018;36;1;00015. Print 2018 Jan-Mar.
To evaluate the association between fraction of exhaled nitric oxide (FeNO) values and forced expiratory volume in the first second (FEV1) and the level of asthma control, as proposed by the Global Initiative for Asthma (GINA), in asthmatic children and adolescents attended at the National Institute of Women, Children and Adolescents Health Fernandes Figueira of Fundação Oswaldo Cruz (IFF/FIOCRUZ).
This was a cross-sectional study, with a review of medical records of 90 asthmatics between 7 and 17 years old, who were followed up at the IFF/FIOCRUZ Asthma Outpatient Clinic and were referred to perform respiratory function tests (RFT)between March 2013 and September 2014. After classification according to GINA, patients performed complete spirometry and FeNO measurement. Subsequently, they were separated into two groups: regular and non-regular inhaled corticosteroid (ICS) use, regardless of the ventilatory pattern in spirometry.
The association between FEV1 values and the degree of asthma control according to GINA (p=0.001) was observed in all patients, regardless of ICS use, but there was no association between FEV1 and levels of FeNO.
The correlation observed between GINA and FEV1 reinforces the importance of spirometry in the clinical follow-up of these patients. Although no association was found between the value of FeNO and the degree of asthma control and FEV1, FeNO may be an early method to detect airway inflammation, even before the symptoms and spirometric changes.
在奥斯瓦尔多·克鲁兹基金会费尔南德斯·菲格雷拉国家妇女、儿童和青少年健康研究所（IFF/FIOCRUZ）就诊的哮喘儿童和青少年中，按照全球哮喘防治创议（GINA）的提议，评估呼出一氧化氮分数（FeNO）值与第一秒用力呼气量（FEV1）及哮喘控制水平之间的关联。
这是一项横断面研究，回顾了90名7至17岁哮喘患者的病历，这些患者在IFF/FIOCRUZ哮喘门诊接受随访，并于2013年3月至2014年9月被转诊进行呼吸功能测试（RFT）。根据GINA进行分类后，患者进行了完整的肺量计检查和FeNO测量。随后，他们被分为两组：规律和不规律吸入糖皮质激素（ICS）使用者，无论肺量计检查中的通气模式如何。
在所有患者中，无论是否使用ICS，均观察到FEV1值与根据GINA划分的哮喘控制程度之间存在关联（p = 0.001），但FEV1与FeNO水平之间无关联。
观察到的GINA与FEV1之间的相关性强化了肺量计检查在这些患者临床随访中的重要性。尽管未发现FeNO值与哮喘控制程度及FEV1之间存在关联，但FeNO可能是一种在症状和肺量计变化出现之前检测气道炎症的早期方法。
