Goldblum M C, Gomez C M, Dalla Barba G, Boller F, Deweer B, Hahn V, Dubois B
U.324 INSERM, Centre Paul Broca, Paris, France.
Neuropsychologia. 1998 Aug;36(8):717-29. doi: 10.1016/s0028-3932(98)00007-4.
Previous results from a population of patients with Alzheimer's disease (Dalla Barba and Goldblum, 1996) demonstrated that the ability of patients to make a semantic association between two items was significantly and positively correlated to their performance on a yes/no recognition task for the same items and that patients who were impaired on the semantic task did significantly worse on the recognition task than patients who were unimpaired on the semantic task. These findings gave support to a hierarchical model of organization of human memory in which episodic memory depends on the integrity of semantic memory. The present study further investigates the relationship between semantic memory deficits and episodic recognition memory in 15 patients with Alzheimer's disease and 15 controls, as a function of their semantic and perceptual encoding abilities and of their cognitive impairment in other domains. The results confirmed the previous findings and showed that, although patients heavily relied on perceptual analysis, this type of encoding did not enhance their recognition memory. Correlations analyses showed that some patients who were not impaired in the semantic association, but with particularly low scores on a verbal fluency task presented with a pattern, in recognition memory tasks, that suggests a possible early involvement of frontal lobes in this subgroup of patients.
先前对一群阿尔茨海默病患者的研究结果（达拉·巴尔巴和戈德布卢姆，1996年）表明，患者在两个项目之间建立语义关联的能力与他们在相同项目的是/否识别任务中的表现显著正相关，并且在语义任务中受损的患者在识别任务中的表现明显比在语义任务中未受损的患者差。这些发现支持了一种人类记忆组织的层次模型，其中情景记忆依赖于语义记忆的完整性。本研究进一步调查了15名阿尔茨海默病患者和15名对照者的语义记忆缺陷与情景识别记忆之间的关系，这是他们语义和感知编码能力以及其他领域认知障碍的函数。结果证实了先前的发现，并表明，尽管患者严重依赖感知分析，但这种编码方式并未增强他们的识别记忆。相关性分析表明，一些在语义关联方面未受损，但在言语流畅性任务中得分特别低的患者，在识别记忆任务中呈现出一种模式，这表明额叶可能在这一亚组患者中早期就已受累。
