Chang F C, Chen K J, Lin J G, Hong C Y, Huang Y T
Xiyuan Hospital and Institute of Geriatrics, China Academy of Traditional Chinese Medicine, Beijing.
J Pharm Pharmacol. 1998 Aug;50(8):881-4. doi: 10.1111/j.2042-7158.1998.tb04003.x.
The effects of tetramethylpyrazine, an alkaloid isolated from a Chinese herb Ligusticum wallichii Franch have been assessed in portal hypertensive rats. Portal hypertension was induced by partial portal vein ligation in Sprague-Dawley rats. Two weeks after ligation, when the hyperdynamic state had stabilized, rats were anaesthetized after an overnight fast and cannulated for measurement of mean arterial pressure, portal venous pressure, cardiac index and heart rate. Tetramethylpyrazine (3.0, 9.9 and 30mgkg(-1)) induced dose-dependent reductions of portal venous pressure and mean arterial pressure after intravenous infusion. The maximum percentage reduction of portal venous pressure after tetramethylpyrazine was 6.0+/-0.8, 9.3+/-1.6 and 20+/-2% of baseline for doses of 3.0, 9.9 and 30.0mgkg(-1), respectively. Also, total peripheral resistance was significantly reduced by tetramethylpyrazine and cardiac index was slightly increased. Our results showed that tetramethylpyrazine induced portal pressure reduction in portal hypertensive rats.
从中药材川芎中分离出的生物碱四甲基吡嗪对门静脉高压大鼠的作用已得到评估。门静脉高压是通过在Sprague-Dawley大鼠中部分结扎门静脉诱导产生的。结扎两周后，当高动力状态稳定时，大鼠在禁食过夜后麻醉，并插管测量平均动脉压、门静脉压、心脏指数和心率。静脉输注四甲基吡嗪（3.0、9.9和30mgkg(-1)）后，门静脉压和平均动脉压呈剂量依赖性降低。四甲基吡嗪给药后，门静脉压降低的最大百分比分别为3.0、9.9和30.0mgkg(-1)剂量下基线值的6.0±0.8%、9.3±1.6%和20±2%。此外，四甲基吡嗪显著降低了总外周阻力，心脏指数略有增加。我们的结果表明，四甲基吡嗪可降低门静脉高压大鼠的门静脉压力。
