Liu T B, Lin H C, Huang Y T, Sun C M, Hong C Y
Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
J Pharm Pharmacol. 1997 Jan;49(1):85-8. doi: 10.1111/j.2042-7158.1997.tb06757.x.
The portal hypotensive effects of tetrandrine and verapamil (both calcium-channel blockers) were assessed in portal hypertensive rats. Portal hypertension was induced by partial portal vein ligation in Sprague-Dawley rats. Both tetrandrine (4, 8, 16 and 24 mg kg-1) and verapamil (0.5, 1.0, 1.5 and 2.0 mg kg-1) induced dose-dependent decreases of portal venous pressure and mean arterial pressure after intravenous infusion. for example, infusion of tetrandrine (16 mg kg-1) induced a maximum reduction of portal venous pressure and mean arterial pressure approximately 1 min after the start of infusion. Portal venous pressure decreased from baseline (12.5 mmHg) to 10.0 mmHg, and mean arterial pressure from baseline (90 mmHg) to 80 mmHg. Heart rate decreased from 250 to 240 beats min-1. At 24 mg kg-1, tetrandrine reduced portal venous pressure and mean arterial pressure to 20.3 +/- 2.4% and 28.4 +/- 1.4% of baseline, respectively. Our results show that both tetrandrine and verapamil induce portal pressure reduction in portal hypertensive animals.
在门静脉高压大鼠中评估了粉防己碱和维拉帕米（两者均为钙通道阻滞剂）的门脉降压作用。门静脉高压通过在Sprague-Dawley大鼠中部分门静脉结扎诱导产生。静脉输注后，粉防己碱（4、8、16和24 mg kg-1）和维拉帕米（0.5、1.0、1.5和2.0 mg kg-1）均引起门静脉压力和平均动脉压的剂量依赖性降低。例如，输注粉防己碱（16 mg kg-1）在输注开始后约1分钟诱导门静脉压力和平均动脉压最大程度降低。门静脉压力从基线（12.5 mmHg）降至10.0 mmHg，平均动脉压从基线（90 mmHg）降至80 mmHg。心率从250次/分钟降至240次/分钟。在24 mg kg-1时，粉防己碱分别将门静脉压力和平均动脉压降至基线的20.3±2.4%和28.4±1.4%。我们的结果表明，粉防己碱和维拉帕米均可使门静脉高压动物的门静脉压力降低。
