Scanziani M, Gähwiler B H, Charpak S
Laboratoire de Physiologie, Ecole Supérieure de Physique et Chimie Industrielles, F-75231 Paris, France.
Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):12004-9. doi: 10.1073/pnas.95.20.12004.
In the hippocampus, a CA3 pyramidal cell forms excitatory synapses with thousands of other pyramidal cells and inhibitory interneurons. By using sequential paired recordings from three connected cells, we show that the presynaptic properties of CA3 pyramidal cell terminals, belonging to the same axon, differ according to the type of target cell. Activation of presynaptic group III metabotropic glutamate receptors decreases transmitter release only at terminals contacting CA1 interneurons but not CA1 pyramidal cells. Furthermore, terminals contacting distinct target cells show different frequency facilitation. On the basis of these results, we conclude that the pharmacological and physiological properties of presynaptic terminals are determined, at least in part, by the target cells.
在海马体中，一个CA3锥体细胞与数千个其他锥体细胞和抑制性中间神经元形成兴奋性突触。通过对三个相连细胞进行连续配对记录，我们发现，属于同一轴突的CA3锥体细胞终末的突触前特性因靶细胞类型而异。突触前III组代谢型谷氨酸受体的激活仅在与CA1中间神经元接触的终末降低递质释放，而与CA1锥体细胞接触的终末则不会。此外，与不同靶细胞接触的终末表现出不同的频率易化。基于这些结果，我们得出结论，突触前终末的药理学和生理学特性至少部分由靶细胞决定。
