Jensen G, Friedenberg F, Levine G, Zaeri N, Braitman L E, Tran H D, Gujral N, Proenza J
Department of Medicine, Albert Einstein Medical Center, Philadelphia, PA, USA.
Nucl Med Commun. 1998 Aug;19(8):771-5. doi: 10.1097/00006231-199808000-00007.
The aim of this study was to evaluate the accuracy of the 14C-urea breath test by comparing the results to those obtained by endoscopy with mucosal biopsy. We also examined the value of the breath test result obtained prior to endoscopy in predicting peptic ulcer disease. Forty-two individuals underwent the 14C-urea breath test. Collections of expired C02 were analysed using a liquid scintillation counter. All individuals then underwent endoscopy with biopsy. Biopsy material was evaluated by the rapid urease method and by histology for the presence of H. pylori. Our results demonstrated that the 14C-urea breath test was 100% sensitive and specific when compared to the rapid urease test as the 'gold standard' for the detection of H. pylori. In comparison to pathology, the sensitivity remained 100% and the specificity was 89%. The results of the 14C-urea breath test had a poor predictive value for the determination of peptic ulcer disease. We conclude that the 14C-urea breath test can be easily performed at any medical facility equipped with a liquid scintillation counter and can accurately detect H. pylori. A negative breath test result could not exclude the presence of peptic ulcer disease.
本研究的目的是通过将14C-尿素呼气试验的结果与内镜黏膜活检的结果进行比较，来评估该试验的准确性。我们还研究了内镜检查前呼气试验结果对预测消化性溃疡疾病的价值。42名个体接受了14C-尿素呼气试验。使用液体闪烁计数器分析呼出的CO2。然后所有个体都接受了内镜活检。活检材料通过快速尿素酶法和组织学检查来评估是否存在幽门螺杆菌。我们的结果表明，与作为检测幽门螺杆菌“金标准”的快速尿素酶试验相比，14C-尿素呼气试验的敏感性和特异性均为100%。与病理学检查相比，敏感性仍为100%，特异性为89%。14C-尿素呼气试验结果对确定消化性溃疡疾病的预测价值较差。我们得出结论，14C-尿素呼气试验在任何配备液体闪烁计数器的医疗设施中都能轻松进行，并且能够准确检测幽门螺杆菌。呼气试验结果为阴性并不能排除消化性溃疡疾病的存在。
