Allardyce R A, Chapman B A, Tie A B, Burt M J, Yeo K J, Keenan J I, Bagshaw P F
Department of Surgery, Christchurch School of Medicine, New Zealand.
Aust N Z J Surg. 1997 Jan;67(1):31-4. doi: 10.1111/j.1445-2197.1997.tb01890.x.
The treatment of H. pylori-associated gastroduodenal disease is increasingly aimed at bacterial eradication which requires follow-up assessment of therapeutic effectiveness and re-infection. A simplified 37 kBq 14C-urea breath test for H. pylori infection has been developed.
The 37 kBq 14C-urea breath test was compared with biopsy urease (CLO) and histological analyses of gastric-biopsies obtained from 63 patients undergoing endoscopy.
The 30-min breath test correlated closely with biopsy findings, had a sensitivity of 100%, a specificity of 95% and a positive predictive value of 92%.
The simplified, low-dose, 14C-urea breath test is a convenient, low-cost, transportable means of facilitating the management of H. pylori-associated diseases.
幽门螺杆菌相关胃十二指肠疾病的治疗越来越旨在根除细菌，这需要对治疗效果和再感染进行随访评估。已开发出一种简化的37 kBq 14C -尿素呼气试验用于检测幽门螺杆菌感染。
将37 kBq 14C -尿素呼气试验与活检尿素酶（CLO）以及对63例接受内镜检查患者所取胃活检组织的组织学分析进行比较。
30分钟呼气试验与活检结果密切相关，敏感性为100%，特异性为95%，阳性预测值为92%。
简化的低剂量14C -尿素呼气试验是一种方便、低成本、可携带的方法，有助于幽门螺杆菌相关疾病的管理。
