Larisch R, Meyer W, Klimke A, Kehren F, Vosberg H, Müller-Gärtner H W
Clinic for Nuclear Medicine, University of Dusseldorf, Germany.
Nucl Med Commun. 1998 Aug;19(8):781-7. doi: 10.1097/00006231-199808000-00009.
Brain functions may be lateralized to the right or the left hemisphere. However, the biochemical characteristics accompanying these functions are largely unknown. To test possible lateralization of striatal dopamine D2 receptors, we examined 18 volunteers using 123I-iodobenzamide and single photon emission tomography. The striatum-to-cerebellum D2 binding ratio was 1.93 +/- 0.22 (mean +/- S.D.) on the right side and 1.85 +/- 0.19 on the left side. In 14 subjects, D2 binding was higher in the right compared to the left striatum (P < 0.05). These results are supported by a meta-analysis performed on 15 studies reported in the literature. We conclude that side differences of striatal dopamine D2 receptors exist. We propose that motor activity could be responsible for our findings.
脑功能可能定位于右侧或左侧半球。然而，伴随这些功能的生化特征在很大程度上尚不清楚。为了测试纹状体多巴胺D2受体可能的定位情况，我们使用123I-碘苄胺和单光子发射断层扫描对18名志愿者进行了检查。右侧纹状体与小脑的D2结合比率为1.93±0.22（平均值±标准差），左侧为1.85±0.19。在14名受试者中，右侧纹状体的D2结合高于左侧（P<0.05）。这些结果得到了对文献中报道的15项研究进行的荟萃分析的支持。我们得出结论，纹状体多巴胺D2受体存在左右差异。我们认为运动活动可能是我们这一发现的原因。
