Dekhuijzen P N
Academisch Ziekenhuis, afd. Longziekten, Nijmegen.
Ned Tijdschr Geneeskd. 1998 Jun 13;142(24):1369-74.
When prescribing inhalation medication in the ambulant treatment of patients with asthma and chronic obstructive pulmonary disease (COPD), a choice can be made between dry powder inhaler (DPI) and pressurized metered dose inhalers (pMDI). The degree of deposition in the lower airways depends on the dose delivery via the inhaler and the mean diameter of the released particles (MMAD). With a DPI, dose delivery and MMAD depend on the inspiratory flow rate. With a pMDI dose delivery and MMAD do not depend on the inspiratory flow rate but on hand-mouth co-ordination. The main determinants for the choice of a DPI or a pMDI are the degree of co-operation and co-ordination, and the inspiratory flow rate of the patient.
在为哮喘和慢性阻塞性肺疾病（COPD）患者进行门诊治疗而开具吸入药物处方时，可以在干粉吸入器（DPI）和压力定量吸入器（pMDI）之间做出选择。在下呼吸道的沉积程度取决于通过吸入器输送的剂量以及释放颗粒的平均直径（MMAD）。使用DPI时，剂量输送和MMAD取决于吸气流量。使用pMDI时，剂量输送和MMAD不取决于吸气流量，而是取决于手口协调性。选择DPI或pMDI的主要决定因素是患者的合作与协调程度以及吸气流量。
