Rothberg S, Nancarrow G E, Meydrech E F, Iwanik M J
Cell Tissue Kinet. 1976 Sep;9(5):439-44. doi: 10.1111/j.1365-2184.1976.tb01294.x.
The removal of the topmost cell layers of the epidermal stratum corneum by stripping initiates a series of biochemical events which alters the normal homeostatic control of and results in the acceleration of the cell cycle in basal cells which are ten to twenty cell layers removed from the site of stripping. One measure of accelerated events is a stimulation of thymidine incorporation into epidermal DNA at time intervals following stripping. Two peaks of maximal stimulation occur between 12 and 24 hr and 48 and 54 hr after stripping. Stimulation of thymidine incorporation into epidermal DNA by limited stripping is a useful technique for studying the stripping-initiated signal at the stratum corneum and its subsequent translation at the proliferative cell receptor site.
通过剥离去除表皮角质层的最上层细胞会引发一系列生化事件，这些事件会改变正常的稳态控制，并导致从剥离部位移除十到二十个细胞层的基底细胞的细胞周期加速。加速事件的一个衡量标准是在剥离后的时间间隔内刺激胸腺嘧啶核苷掺入表皮DNA。最大刺激的两个峰值出现在剥离后12至24小时以及48至54小时之间。通过有限剥离刺激胸腺嘧啶核苷掺入表皮DNA是一种用于研究角质层处剥离引发的信号及其在增殖细胞受体位点的后续转化的有用技术。
