Molès J P
Laboratoire de dermatologie moléculaire, Institut universitaire de recherche clinique, Montpellier.
Bull Cancer. 1998 Mar;85(3):207-8.
Interaction between developmental biology and human pathology has brought new insight on basal cell carcinoma oncogenesis. Alterations of the Patched gene appear to be responsible for the Gorlin syndrome and to be detected in 50% of the sporadic basal cell carcinomas. This relation has recently been extended to all the components of the Hedgehog signalling pathway.
发育生物学与人类病理学之间的相互作用为基底细胞癌的肿瘤发生带来了新的见解。Patched基因的改变似乎是导致戈林综合征的原因，并且在50%的散发性基底细胞癌中可以检测到。这种关系最近已扩展到刺猬信号通路的所有组成部分。
