Bercovici J P, Roudaut N, Kerlan V, Aupetit-Faisant B, Floch H H
CHU Brest Hôpital Cavale Blanche.
Ann Endocrinol (Paris). 1998 Apr;59(1):20-2.
The aim of the study was to evaluate dexamethazone test in a patient with primary aldosteronism caused by an adrenocortical adenoma. We observed a 50% decrease of plasma aldosterone as in glucocorticoid suppressible aldosteronism (GSA) but absolute value of aldosterone remained higher than 40 pg/ml. Basal plasma and urinary values of 18 OXO and 18 OH cortisol were not significantly elevated as in GSA. Inversely, the evaluation of 11 beta-hydroxylase activity of mineralocorticoids was in favor of a benign adrenal tumor.
本研究的目的是评估地塞米松试验在一名由肾上腺皮质腺瘤引起的原发性醛固酮增多症患者中的应用。我们观察到血浆醛固酮水平下降了50%,与糖皮质激素可抑制性醛固酮增多症(GSA)情况相同,但醛固酮的绝对值仍高于40 pg/ml。与GSA不同,18-氧代皮质醇和18-羟皮质醇的基础血浆和尿液值没有显著升高。相反,盐皮质激素11β-羟化酶活性的评估结果支持肾上腺良性肿瘤的诊断。