Dartevelle P, Fadel E, Chapelier A, Macchiarini P, Cerrina J, Leroy-Ladurie F, Parquin F, Simonneau F, Parent F, Humbert M, Simonneau G
Service de chirurgie thoracique vasculaire et de transplantation cardiopulmonaire, hôpital Marie-Lannelongue, Le Plessis-Robinson, France.
Chirurgie. 1998 Feb;123(1):32-40. doi: 10.1016/s0001-4001(98)80036-6.
The best predictor of poor or suboptimum outcome from pulmonary thromboendarterectomy (PTE) is insufficient relief of obstruction, especially in the lower lobes. The aim of this study is to emphasize that the use of video-assisted angioscopy may increase the quality of PTE and thus improve outcome. PTE included a median sternotomy, intrapericardial dissection limited to the superior vena cava, institution of cardiopulmonary bypass, deep hypothermia and sequential circulatory arrest periods. PTE was always bilateral and performed through two separate arteriotomies of both main intrapericardial pulmonary arteries. A rigid 5 mm angioscope connected to a video camera was introduced through the arteriotomy into the lumen to increase the visibility and perform the video-assisted endarterectomies of all obstructed segmental branches, including normally inaccessible anterior segmental branches. Between January 1996 and December 1997, 48 patients with severe postembolic pulmonary hypertension had PTE. Patients were in New York Heart Association (NYHA) class II (n = 2), III (n = 28) or IV (n = 18) with the following hemodynamics: mean pulmonary arterial pressure (PAP) 53 +/- 13 mmHg, cardiac index 2.16 +/- 0.5 L/min/m2, pulmonary vascular resistances (PVR): 1,152 +/- 414 dyne.s-1.cm-5. Six patients died from alveolar hemorrhage (n = 1), high residual pulmonary pressure and rethrombosis (n = 4) and hypoxic cardiac arrest (n = 1). The functional outcome in surviving patients was as follows: (NYHA) class I (n = 24), II (n = 16) or III (n = 2) with improved hemodynamics: mean pulmonary arterial pressure: 30 +/- 9 mmHg, cardiac index: 2.78 +/- 0.5 L/min/m2, pulmonary vascular resistances (PVR): 484 +/- 159 dynes.s-1.cm-5. Video-assisted angioscopy allows much improved quality and degree of pulmonary endarterectomy. This expands the indications to include patients with previously inaccessible distal disease and candidates for heart-lung transplantation.
肺血栓内膜剥脱术(PTE)预后不良或欠佳的最佳预测因素是梗阻缓解不充分,尤其是在下叶。本研究的目的是强调使用电视辅助血管镜检查可能会提高PTE的质量,从而改善预后。PTE包括正中胸骨切开术、仅限于上腔静脉的心包内解剖、建立体外循环、深度低温和序贯循环停止期。PTE总是双侧进行,通过心包内两条主要肺动脉的两个单独动脉切口进行。将连接到摄像机的5毫米硬式血管镜通过动脉切口插入管腔,以增加视野并对所有阻塞的节段性分支进行电视辅助内膜剥脱术,包括通常难以到达的前段分支。1996年1月至1997年12月,48例严重栓塞后肺动脉高压患者接受了PTE。患者处于纽约心脏协会(NYHA)II级(n = 2)、III级(n = 28)或IV级(n = 18),具有以下血流动力学指标:平均肺动脉压(PAP)53±13 mmHg,心脏指数2.16±0.5 L/min/m²,肺血管阻力(PVR):1152±414 dynes·s⁻¹·cm⁻⁵。6例患者死于肺泡出血(n = 1)、高残留肺动脉压和再血栓形成(n = 4)以及缺氧性心脏骤停(n = 1)。存活患者的功能结局如下:(NYHA)I级(n = 24)、II级(n = 16)或III级(n = 2),血流动力学改善:平均肺动脉压:30±9 mmHg,心脏指数:2.78±0.5 L/min/m²,肺血管阻力(PVR):484±159 dynes·s⁻¹·cm⁻⁵。电视辅助血管镜检查可显著提高肺内膜剥脱术的质量和程度。这扩大了适应症,包括以前难以到达的远端疾病患者和心肺移植候选人。