Ashmore J P, Krewski D, Zielinski J M, Jiang H, Semenciw R, Band P R
Radiation Protection Bureau, Health Canada, Ottawa, Ontario.
Am J Epidemiol. 1998 Sep 15;148(6):564-74. doi: 10.1093/oxfordjournals.aje.a009682.
A cohort mortality study of occupational radiation exposure was conducted using the records of the National Dose Registry of Canada. The cohort consisted of 206,620 individuals monitored for radiation exposure between 1951 and 1983 with mortality follow-up through December 31, 1987. A total of 5,426 deaths were identified by computerized record linkage with the Canadian Mortality Data Base. The standardized mortality ratio for all causes of death was 0.61 for both sexes combined. However, trends of increasing mortality with cumulative exposure to whole body radiation were noted for all causes of death in both males and females. In males, cancer mortality appeared to increase with cumulative exposure to radiation, without any clear relation to specific cancers. Unexplained trends of increasing mortality due to cardiovascular diseases (males and females) and accidents (males only) were also noted. The excess relative risk for both sexes, estimated to be 3.0% per 10 mSv (90% confidence interval 1.1-4.8) for all cancers combined, is within the range of risk estimates previously reported in the literature.
利用加拿大国家剂量登记处的记录开展了一项职业性辐射暴露队列死亡率研究。该队列由206,620名个体组成，这些个体在1951年至1983年期间接受了辐射暴露监测，并对其进行死亡率随访直至1987年12月31日。通过与加拿大死亡率数据库进行计算机化记录链接，共识别出5426例死亡病例。男女合并的所有死因标准化死亡率为0.61。然而，在男性和女性中，均注意到随着全身辐射累积暴露量增加，所有死因的死亡率呈上升趋势。在男性中，癌症死亡率似乎随着辐射累积暴露量增加而上升，与特定癌症无明显关联。还注意到心血管疾病（男性和女性）和事故（仅男性）导致的死亡率出现不明原因的上升趋势。所有癌症合并的男女超额相对风险估计为每10毫希沃特3.0%（90%置信区间1.1 - 4.8），在先前文献报道的风险估计范围内。
