Pernerstorfer T, Stohlawetz P, Stummvoll G, Kapiotis S, Szekeres T, Eichler H G, Jilma B
Department of Clinical Pharmacology, Clinical Institute of Medical and Chemical Laboratory Diagnostics, Vienna, Austria.
Br J Haematol. 1998 Sep;102(5):1229-31. doi: 10.1046/j.1365-2141.1998.00883.x.
Smoking causes atherosclerosis, and smokers have increased thromboxane (TXA2) formation. As aspirin inhibits TXA2 production we speculated that smokers would preferentially profit from inhibition of the TXA2 pathway by aspirin. Increased expression of P-selectin, a constituent of the alpha-granules of platelets, and increased levels of circulating (c)P-selectin in plasma are markers for platelet activation. The aim of this study was to compare P-selectin expression on platelets between smokers and nonsmokers, and to compare with placebo the effect of 2 weeks administration of 100 mg/d aspirin on platelet activation in smokers. Smokers exhibited higher P-selectin expression on platelets than non-smokers (2.7+/-1.8% v 1.6+/-0.6%, P=0.018), thus confirming increased platelet activation. Aspirin did not reduce platelet activation as demonstrated by unchanged P-selectin expression on platelets and cP-selectin plasma levels.
吸烟会导致动脉粥样硬化，吸烟者血栓素（TXA2）的生成会增加。由于阿司匹林可抑制TXA2的产生，我们推测吸烟者会优先从阿司匹林对TXA2途径的抑制中获益。血小板α颗粒成分P-选择素的表达增加以及血浆中循环（c）P-选择素水平升高是血小板活化的标志物。本研究的目的是比较吸烟者和非吸烟者血小板上P-选择素的表达，并比较给予吸烟者每天100毫克阿司匹林，持续2周对血小板活化的影响与安慰剂的效果。吸烟者血小板上的P-选择素表达高于非吸烟者（2.7±1.8%对1.6±0.6%，P=0.018），从而证实血小板活化增加。如血小板上P-选择素表达和cP-选择素血浆水平未改变所示，阿司匹林并未降低血小板活化。
