Balabanov R, Dore-Duffy P
Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.
J Neurosci Res. 1998 Sep 15;53(6):637-44. doi: 10.1002/(SICI)1097-4547(19980915)53:6<637::AID-JNR1>3.0.CO;2-6.
Pericytes are a very important cellular constituent of the blood-brain barrier. They play a regulatory role in brain angiogenesis, endothelial cell tight junction formation, blood-brain barrier differentiation, as well as contribute to the microvascular vasodynamic capacity and structural stability. Central nervous system pericytes express macrophage functions and are actively involved in the neuroimmune network operating at the blood-brain barrier. They exhibit unique functional characteristics critical for the pathogenesis of a number of cerebrovascular, neurodegenerative, and neuroimmune diseases.
周细胞是血脑屏障非常重要的细胞组成部分。它们在脑内血管生成、内皮细胞紧密连接形成、血脑屏障分化中发挥调节作用，还对微血管的血管动力学能力和结构稳定性有贡献。中枢神经系统周细胞具有巨噬细胞功能，并积极参与在血脑屏障运行的神经免疫网络。它们表现出独特的功能特性，对许多脑血管疾病、神经退行性疾病和神经免疫疾病的发病机制至关重要。
