Kostopanagiotou G, Pouriezis T, Theodoraki K, Kottis G, Andreadou I, Smyrniotis V, Papadimitriou L
Department of Anaesthesia, University of Athens, Areteion Hospital, Greece.
J Clin Pharmacol. 1998 Sep;38(9):825-9.
Ondansetron, a selective 5-HT3 antagonist has been proved to be an effective antiemetic agent for prophylaxis of nausea and vomiting after surgery. This study was conducted to determine whether ondansetron changes thiopental requirements for induction of anesthesia in patients unpremedicated and premedicated with diazepam. One hundred sixty eight adult female patients classified as American Society of Anesthesiologists (ASA) physical status I (normal healthy patient) or II (patient with mild systemic disease) participated in this prospective, double blinded, randomized study. Patients were assigned to receive either 0.07 mg/Kg diazepam orally or no premedication. They then received saline and ondansetron 0.1 mg/Kg or 0.2 mg/Kg intravenously 5 minutes before thiopental induction. Thiopental was administered at a rate of 25 mg/min until the patient lost the ability to open eyes on command. Thiopental requirements were not significantly different among groups. The results indicate that ondansetron in clinically used doses does not influence the hypnotic requirements of thiopental.
昂丹司琼是一种选择性5-羟色胺3拮抗剂，已被证明是预防术后恶心和呕吐的有效止吐药。本研究旨在确定昂丹司琼是否会改变未用术前药和用安定进行术前用药患者诱导麻醉时硫喷妥钠的需求量。168名成年女性患者被分类为美国麻醉医师协会（ASA）身体状况I级（正常健康患者）或II级（轻度全身性疾病患者），参与了这项前瞻性、双盲、随机研究。患者被分配接受口服0.07mg/Kg安定或不进行术前用药。然后在硫喷妥钠诱导前5分钟，他们静脉接受生理盐水和0.1mg/Kg或0.2mg/Kg昂丹司琼。硫喷妥钠以25mg/分钟的速度给药，直到患者失去按指令睁眼的能力。硫喷妥钠需求量在各组之间无显著差异。结果表明，临床使用剂量的昂丹司琼不影响硫喷妥钠的催眠需求量。
