Koszyca B, Blumbergs P C, Manavis J, Wainwright H, James R, Gilbert J, Jones N, Reilly P L
Department of Pathology, University of Adelaide, South Australia, Australia.
J Neurotrauma. 1998 Sep;15(9):675-83. doi: 10.1089/neu.1998.15.675.
In order to determine whether axonal injury (AI) is a factor in cases of penetrating head injury, the brains of 14 patients who died shortly after sustaining a fatal gunshot wound (GSW) to the head were examined, and the presence of AI determined using immunohistochemical staining for amyloid precursor protein (APP). The distribution of AI was mapped throughout the cerebral hemispheres and brain stem. AI was present in all cases in a diffuse distribution distant to the missle track with severe involvement of the brain stem in all cases. There was no axonal APP immunoreactivity in the direct region of the missle track at the point of primary axotomy. The APP-positive AI in these cases is likely to be a mixture of primary and secondary AI as APP immunostaining is unable to distinguish primary AI due to mechanical deformation from AI secondary to hypoxic-ischemic damage.
为了确定轴突损伤（AI）是否为穿透性颅脑损伤病例中的一个因素，对14例头部遭受致命枪伤（GSW）后不久死亡的患者的大脑进行了检查，并使用淀粉样前体蛋白（APP）免疫组化染色来确定AI的存在。AI的分布在整个大脑半球和脑干中进行了定位。在所有病例中均存在AI，呈弥漫性分布，远离导弹轨迹，且所有病例的脑干均严重受累。在初次轴突切断点的导弹轨迹直接区域内没有轴突APP免疫反应性。这些病例中APP阳性的AI可能是原发性和继发性AI的混合，因为APP免疫染色无法区分机械变形导致的原发性AI和缺氧缺血性损伤继发的AI。
