Gentleman S M, Nash M J, Sweeting C J, Graham D I, Roberts G W
Department of Psychiatry, Charing Cross and Westminster Medical School, London UK.
Neurosci Lett. 1993 Oct 1;160(2):139-44. doi: 10.1016/0304-3940(93)90398-5.
It has been demonstrated recently that beta-amyloid protein (beta AP), generally associated with the plaques of Alzheimer's disease, can also be found in the brains of survivors of head injury. In this study the distribution of the beta AP precursor protein (beta APP) was examined immunohistochemically to determine if it is colocalized with beta AP in such cases. beta APP immunoreactivity was observed in neuronal perikarya in the neocortex and in dystrophic neurites surrounding beta AP immunoreactive plaques i.e. in a distribution similar to that seen in Alzheimer's disease. In addition, beta APP immunoreactivity was noted within white matter tracts where it marked damaged axons. However, no colocalisation of beta APP with beta AP was observed in any white matter region. These results indicate that processing of beta APP to produce beta AP occurs in the synaptic terminal field of axons and illustrate the utility of beta APP immunoreactivity as a general marker for axonal injury.
最近有研究表明，通常与阿尔茨海默病斑块相关的β-淀粉样蛋白（β-AP）也可在头部受伤幸存者的大脑中发现。在本研究中，采用免疫组织化学方法检测β-AP前体蛋白（β-APP）的分布，以确定在这些病例中它是否与β-AP共定位。在新皮质的神经元胞体以及β-AP免疫反应性斑块周围的营养不良性神经突中观察到β-APP免疫反应性，即其分布与阿尔茨海默病中所见相似。此外，在白质束中也注意到β-APP免疫反应性，其标记了受损的轴突。然而，在任何白质区域均未观察到β-APP与β-AP的共定位。这些结果表明，β-APP加工产生β-AP发生在轴突的突触终末场，并说明了β-APP免疫反应性作为轴突损伤通用标志物的实用性。
