Wetscher G J, Glaser K, Wieschemeyer T, Gadenstätter M, Klingler P, Klingler A, Hinder R A
Department of Surgery, University of Innsbruck, Austria.
Dig Dis Sci. 1998 Sep;43(9):1986-90. doi: 10.1023/a:1018890727053.
Partial posterior fundoplication improves esophageal peristalsis in patients with gastroesophageal reflux disease (GERD) associated with poor esophageal body function. The aim of this study was to investigate whether postoperative administration of cisapride enhances the effect of surgery on esophageal peristalsis. Laparoscopic partial posterior fundoplication was performed on 34 consecutive GERD patients with poor esophageal body motility. These patients were randomized in groups without and with postoperative treatment with cisapride 20 mg twice daily for six months. Esophageal manometry was performed preoperatively and six months following surgery. Esophageal body function improved significantly following partial posterior fundoplication without or with postoperative treatment with cisapride. However, this effect was more pronounced in the group of patients receiving cisapride. Partial posterior fundoplication combined with postoperative treatment with cisapride should be the therapy of choice in GERD patients with poor esophageal body motility.
部分后位胃底折叠术可改善食管体部功能不佳的胃食管反流病（GERD）患者的食管蠕动。本研究的目的是探讨术后给予西沙必利是否能增强手术对食管蠕动的效果。对34例连续的食管体部动力不佳的GERD患者进行了腹腔镜部分后位胃底折叠术。这些患者被随机分为两组，一组术后不接受治疗，另一组术后接受每日两次、每次20 mg西沙必利治疗，持续6个月。术前及术后6个月进行食管测压。无论术后是否接受西沙必利治疗，部分后位胃底折叠术后食管体部功能均有显著改善。然而，在接受西沙必利治疗的患者组中，这种效果更为明显。对于食管体部动力不佳的GERD患者，部分后位胃底折叠术联合术后西沙必利治疗应是首选治疗方法。
