Novoselova E G, Semiletova N V, Makar V R
Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow District, Russia.
Indian J Biochem Biophys. 1998 Apr;35(2):103-7.
Chronic whole-body irradiation (0.43 cGy/day; total doses 11, 23, and 35 cGy) caused non-monotonous long-term disturbances in rat splenic T lymphocytes proliferation. Immunosuppression observed after chronic exposure had no correlation with the splenic cell number and the decrease in the fluorescence intensity of Hoechst 33258-DNA complex in T lymphocytes. Small, but significant radioprotection was observed with Coenzyme Q diet immediately after irradiation. These results indicate that the changes in T cell immunity, T cell viability, and T cell DNA state after exposure to low dose radiation are not interrelated.
慢性全身照射（0.43 厘戈瑞/天；总剂量分别为 11、23 和 35 厘戈瑞）导致大鼠脾脏 T 淋巴细胞增殖出现非单调的长期紊乱。慢性照射后观察到的免疫抑制与脾脏细胞数量以及 T 淋巴细胞中 Hoechst 33258 - DNA 复合物荧光强度的降低无关。照射后立即给予辅酶 Q 饮食可观察到轻微但显著的辐射防护作用。这些结果表明，低剂量辐射暴露后 T 细胞免疫、T 细胞活力和 T 细胞 DNA 状态的变化相互之间没有关联。
