Novoselova E G, Safonova M V, Semiletova N V
Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow region.
Int J Radiat Biol. 1995 Apr;67(4):469-76. doi: 10.1080/09553009514550541.
The dynamics of T and B cell immunity in spleens from rat exposed to whole-body chronic irradiation with dose rates of 12.9 cGy/day (range 1-10 Gy) and 3.0 cGy/day (range 0.57-2.04 Gy) were investigated. gamma-irradiation with a dose-rate of 12.9 cGy/day was shown to produce a wave-like suppression of the T lymphocyte mitogenic response. Irradiation with a dose-rate of 3.0 cGy/day caused a decrease in immune response of T lymphocytes 48 days after onset of exposure (total dose 1.4 Gy). It was also shown that chronic irradiation with a dose-rate of 3.0 cGy/day produced significant changes in the DNA of T lymphocytes. Our results show that the radiation-induced suppression of immune functions and damage to DNA structure were partially eliminated when animals were fed a daily diet supplemented with a natural antioxidant, ubiquinone Q-9. The inhibiting effect of chronic irradiation was more pronounced in B lymphocytes because of their higher radiosensitivity.
研究了大鼠脾脏中T细胞和B细胞免疫动力学，这些大鼠全身接受剂量率分别为12.9 cGy/天（剂量范围1 - 10 Gy）和3.0 cGy/天（剂量范围0.57 - 2.04 Gy）的慢性照射。结果显示，剂量率为12.9 cGy/天的γ射线照射会产生类似波浪状的T淋巴细胞有丝分裂反应抑制。剂量率为3.0 cGy/天的照射在照射开始48天后（总剂量1.4 Gy）导致T淋巴细胞免疫反应下降。还表明，剂量率为3.0 cGy/天的慢性照射会使T淋巴细胞的DNA发生显著变化。我们的结果表明，当给动物喂食补充了天然抗氧化剂泛醌Q - 9的日常饮食时，辐射诱导的免疫功能抑制和DNA结构损伤会部分消除。由于B淋巴细胞的放射敏感性较高，慢性照射对其的抑制作用更为明显。
