Ithayarasi A P, Shyamala Devi C
Department of Biochemistry, University of Madras, Chennai, India.
Indian J Biochem Biophys. 1998 Apr;35(2):115-9.
The effect of alpha-tocopherol pretreatment (6 mg/100 g body wt/day, orally for a period of 90 days) on mitochondrial electron transport in myocardial infarction induced by isoproterenol (20 mg/100 g body wt, subcutaneously for two days) was studied in rats. A significant decrease was observed in the activities of isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, succinate dehydrogenase, malate dehydrogenase, NADH dehydrogenase and cytochrome oxidase in heart mitochondria of isoproterenol administered rats. The cytochrome content and the oxidation of succinate in state 3 and state 4 decreased significantly in the cardiac mitochondria treatment. In alpha-tocopherol pretreated rats, the activities of TCA cycle enzymes, concentration of cytochromes and the oxidation of succinate in state 3 and state 4 were retained at near normal values, following isoproterenol administration.
研究了α-生育酚预处理（6毫克/100克体重/天，口服90天）对异丙肾上腺素（20毫克/100克体重，皮下注射两天）诱导的大鼠心肌梗死中线粒体电子传递的影响。在给予异丙肾上腺素的大鼠心脏线粒体中，观察到异柠檬酸脱氢酶、α-酮戊二酸脱氢酶、琥珀酸脱氢酶、苹果酸脱氢酶、NADH脱氢酶和细胞色素氧化酶的活性显著降低。心脏线粒体处理中，细胞色素含量以及状态3和状态4下琥珀酸的氧化显著降低。在α-生育酚预处理的大鼠中，给予异丙肾上腺素后，三羧酸循环酶的活性、细胞色素浓度以及状态3和状态4下琥珀酸的氧化保持在接近正常的值。
