α-生育酚对异丙肾上腺素诱导的大鼠心肌梗死的影响——心电图、生化及组织学证据
Effect of alpha-tocopherol on isoproterenol induced myocardial infarction in rats--electrocardiographic biochemical and histological evidences.
作者信息
Ithayarasi A P, Padmavathy V N, Shyamala Devi C
机构信息
Department of Biochemistry, University of Madras.
出版信息
Indian J Physiol Pharmacol. 1996 Oct;40(4):297-302.
The effect of alpha-tocopherol (6 mg/100 g body wt, orally, daily for 90 days) pretreatment in isoproterenol (20 mg/100 g body wt, subcutaneously, twice at an interval of two days at the end of the alpha-tocopherol pretreatment) induced myocardial infarction was studied in rats. Isoproterenol administered rats showed electrocardiographic changes suggestive of myocardial infarction with marked ST segment elevation, Q waves appearance and a significant increase in heart rate. In isoproterenol administered rats, a significant decrease was observed in the activities of marker enzymes such as aspartate amino transferase, alanine amino transferase, lactate dehydrogenase and creatine kinase in heart and aorta with a significant increase in their activities in serum. The levels of lipid peroxides in terms of "TBA reactants" increased significantly in serum, heart and aorta on isoproterenol administration. The histology of heart and aorta showed marked fragmentation of muscle fibres and necrotic lesions in isoproterenol administered rats. alpha-Tocopherol pretreated rats showed a near normal ECG pattern, levels of lipid peroxides, activities of marker enzymes and a near normal histology of heart and aorta on isoproterenol administration.
研究了α-生育酚（6毫克/100克体重，口服，每日一次，共90天）预处理对异丙肾上腺素（20毫克/100克体重，皮下注射，在α-生育酚预处理结束时每隔两天注射两次）诱导的大鼠心肌梗死的影响。给予异丙肾上腺素的大鼠出现提示心肌梗死的心电图变化，伴有明显的ST段抬高、Q波出现以及心率显著增加。在给予异丙肾上腺素的大鼠中，观察到心脏和主动脉中天门冬氨酸氨基转移酶、丙氨酸氨基转移酶、乳酸脱氢酶和肌酸激酶等标志物酶的活性显著降低，而血清中这些酶的活性显著增加。给予异丙肾上腺素后，血清、心脏和主动脉中以“TBA反应物”表示的脂质过氧化物水平显著升高。给予异丙肾上腺素的大鼠心脏和主动脉的组织学显示肌肉纤维明显断裂和坏死病变。α-生育酚预处理的大鼠在给予异丙肾上腺素后显示出接近正常的心电图模式、脂质过氧化物水平、标志物酶活性以及心脏和主动脉接近正常的组织学。
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