Martikainen H, Ruokonen A, Hartikainen A L, Järvelin M R
Department of Obstetrics and Gynecology, University of Oulu, Finland.
Int J Circumpolar Health. 1998 Jul;57(2-3):133-7.
About 30% of infertility is caused by anovulation, associated most commonly with the polycystic ovary syndrome (PCOS). PCOS is a common endocrinopathy in women, especially at the age of 30 to 35 years, characterized by irregular menses, infertility and signs of hyperandrogenism. The pathogenetic mechanisms leading to PCOS are not fully understood, although several theories have been proposed. PCOS patients commonly have hyperinsulinemia and insulin resistance which are also known risk factors for the development of diabetes mellitus, hypertension and cardiovascular disease. However, it is not known, how well the presence of PCOS symptoms would predict the appearance of the long-term sequelae of insulin resistance. Also more data is needed e.g. of the role of intrauterine factors and birth weight in the development of PCOS and hyperandrogenism.
约30%的不孕症由无排卵引起，最常见于多囊卵巢综合征（PCOS）。PCOS是女性常见的内分泌疾病，尤其在30至35岁年龄段，其特征为月经不规律、不孕以及高雄激素血症迹象。尽管已提出多种理论，但导致PCOS的发病机制尚未完全明确。PCOS患者通常存在高胰岛素血症和胰岛素抵抗，这也是糖尿病、高血压和心血管疾病发展的已知危险因素。然而，尚不清楚PCOS症状的存在能多准确地预测胰岛素抵抗长期后遗症的出现。此外，还需要更多数据，例如宫内因素和出生体重在PCOS及高雄激素血症发展中的作用。
