Długosz A, Sawicka E
Department of Toxicology Wrocław University of Medicine, Poland.
Int J Occup Med Environ Health. 1998;11(2):153-63.
The influence of coenzyme Q on the lipid parameters in the paint and lacquer industry workers is presented. The examinations were carried out in the group of 24 workers employed at the paint and lacquer production, who received coenzyme Q10 as a chemoprotective agent. Serum concentration of basic lipid parameters: total cholesterol (TC), high density lipoproteins (HDL), low density lipoproteins (LDL), triglycerides (TG); lipid peroxidation products: malonyldialdehyde (MDA) together with 4-hydroxynonenal (4-HNE) and two antioxidant enzymes: superoxide dismutase (SOD) and glutathione peroxidase (GPx) were examined. The above parameters were measured in workers exposed to organic solvents and then after 4 weeks of coenzyme Q treatment. In order to explain, whether the occupational exposure is responsible for the changed level of some parameters, the reference group, not employed in the paint and lacquer industry, was used. The results indicated that the preliminary blood serum concentration of MDA + 4-HNE in workers exposed to organic solvents was significantly elevated in comparison to the control group. Statistically significant decrease in MDA + 4HNE concentration was observed after coenzyme Q treatment what lead to the conclusion that coenzyme Q could be considered as a protective agent against lipid peroxidation in occupational exposure. The changes in other parameters were statistically insignificant.
本文介绍了辅酶Q对油漆和涂料行业工人脂质参数的影响。研究对24名从事油漆和涂料生产的工人进行，他们服用辅酶Q10作为化学保护剂。检测了基本脂质参数的血清浓度：总胆固醇（TC）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、甘油三酯（TG）；脂质过氧化产物：丙二醛（MDA）和4-羟基壬烯醛（4-HNE），以及两种抗氧化酶：超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GPx）。在接触有机溶剂的工人中检测上述参数，然后在辅酶Q治疗4周后再次检测。为了解释职业暴露是否导致某些参数水平的变化，使用了未从事油漆和涂料行业的对照组。结果表明，与对照组相比，接触有机溶剂的工人血清中MDA + 4-HNE的初始浓度显著升高。辅酶Q治疗后，MDA + 4HNE浓度出现统计学显著下降，由此得出结论，辅酶Q可被视为职业暴露中脂质过氧化的保护剂。其他参数的变化无统计学意义。
