Gusha A L, Tarasenko S V, Fedoseev A V
Khirurgiia (Mosk). 1998(8):36-9.
The aim of the study is the development of integral methods for early diagnosis and treatment of systemic pathobiochemical disturbances in patients with diabetes mellitus under conditions of acute surgical endotoxicosis as well as optimisation of surgical policy and drug pathogenetic correction. Blood lipids peroxidation (malonic dyaldehyde content in NADF and ascorbate-dependent systems, intermolecular sewings in erythrocytes membranes) and central hemodynamic parameters. The study was carried out in 199 patients with acute surgical diseases accompanied with diabetes mellitus. Peculiarities of the course of the disease were revealed in dependence of the form of blood lipoperoxidation. The scheme of intensive care in conditions of decompensation of diabetes mellitus aimed at correction of pathobiochemical disturbances in patients with acute surgical endotoxicosis has been developed.
本研究的目的是开发综合方法，用于在急性外科内毒素血症情况下对糖尿病患者的全身病理生化紊乱进行早期诊断和治疗，以及优化手术策略和药物病因学纠正。研究了血脂过氧化（NADF和抗坏血酸依赖系统中的丙二醛含量，红细胞膜中的分子间缝合）和中心血流动力学参数。对199例伴有糖尿病的急性外科疾病患者进行了研究。根据血脂过氧化的形式揭示了疾病过程的特点。已制定了在糖尿病失代偿情况下的重症监护方案，旨在纠正急性外科内毒素血症患者的病理生化紊乱。
