Sato M, Nagata O, Sugai N, Yajima C, Hanaoka K
Department of Anesthesiology, Faculty of Medicine, University of Tokyo.
Masui. 1998 Aug;47(8):968-71.
We examined the difference in the duration of action of vecuronium injected through a venous line infused with propofol and the duration of vecuronium infused into another venous line without propofol, in order to investigate the interaction between vecuronium and propofol within the intravenous lines. The subjects of the study are 8 patients, (ASA grade 1 or 2, aged from 20 to 50 years, 6 males and 2 females), who had undergone elective operations under general anesthesia. The mean duration of action of vecuronium injected through the venous line infused with propofol was 32.3 +/- 9.0 (min), while that for vecuronium injected through the venous line without propofol was 32.1 +/- 8.6 (min). There was no significant difference in the duration of action of vecuronium between the two conditions. We conclude that since vecuronium can be injected through the venous lines infused with propofol without interaction, there is no need for an additional venous line without propofol when vecuronium is administered under propofol anesthesia.
为了研究维库溴铵与丙泊酚在静脉通路中的相互作用，我们检测了经输注丙泊酚的静脉通路注射维库溴铵的作用持续时间与经另一未输注丙泊酚的静脉通路注射维库溴铵的作用持续时间之间的差异。研究对象为8例患者（美国麻醉医师协会分级1或2级，年龄20至50岁，6例男性，2例女性），他们均在全身麻醉下接受择期手术。经输注丙泊酚的静脉通路注射维库溴铵的平均作用持续时间为32.3±9.0（分钟），而经未输注丙泊酚的静脉通路注射维库溴铵的平均作用持续时间为32.1±8.6（分钟）。两种情况下维库溴铵的作用持续时间无显著差异。我们得出结论，由于维库溴铵可通过输注丙泊酚的静脉通路注射而无相互作用，因此在丙泊酚麻醉下给予维库溴铵时无需额外的未输注丙泊酚的静脉通路。
